Reusability report: Meta-learning for antigen-specific T cell receptor binder identification

Nature Machine Intelligence, Published online: 06 May 2026; doi:10.1038/s42256-026-01236-6

He et al. comprehensively test the reusability of PanPep, a meta-learning framework for peptide–TCR binding prediction. The authors demonstrate the utility of PanPep in extended testing scenarios, leveraging proposed independent datasets and negative sampling strategies.