Reusability report: multi-sample omics network inference operates in distinct robustness regimes defined by prior knowledge and data availability

Nature Machine Intelligence, Published online: 19 October 2026; doi:10.1038/s42256-026-01311-y

This work studies the reusability of CORNETO, a previously developed framework for learning biological networks from multi-omics data. Robust network inference is found to depend on data availability, prior knowledge, regularization and biological context.